An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD

Clinical Epigenetics

Table 4 Epigenome-wide significant CpG sites by factor

Factor	CpG	logFC	p value	FDR	Gene
T/N	cg26033520	− 0.4147	1.75e⁻¹⁰	0.0003	ASCC1 (nearby)
	cg23156469	− 0.1939	5.84e⁻⁰⁸	0.0312	FAM20B
	cg15356923	0.2150	8.59e⁻⁰⁸	0.0345	FAM19A4 (aka TAFA4)
A	cg13053408	− 0.0027	5.30e⁻⁰⁸	0.0312	C3orf24 (aka FANCD20S)

n = 704 (lower due to samples failing the GWAS, EWAS or SIMOA QC pipeline). Covariates were age, sex, ancestry PCs 1–3, estimated cell proportions (CD4T, CD8T, B cell, NK and Mono), DNAm-based smoking score, and laboratory analysis batch. FDR correction was based on the total number of probes examined across the two EWASs (1,605,282 probes total)

ISSN: 1868-7083