Fig. 3
From: An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD
Diagram depicting the significant direct paths (ps < 0.001) and associated variables from the SEM results. The Simoa latent variables are represented as circles with the loadings of each indicator shown as well as the correlation between the two factors. Age was the only variable in the model that showed significant (p < 0.001) direct effects on both variables. PC1 was positively associated with Factor A. The EWAS-significant CpG sites were evaluated as mediators of the association between the psychiatric and demographic variables and the latent variables. Significant indirect effects were found for a the effect of age on Factor TN via cg15356923, b the effect of sex on Factor TN via cg26033520, and c the effect of lifetime trauma count on Factor A via cg130534081