Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study

Clinical Epigenetics

Table 1 Heterogeneity, pleiotropy, and tool strength of MR analyses

Exposure	Outcome	Cochran’s Q statistic			Egger intercept		Global test	F-statistic
Exposure	Outcome	P value	Q	I² (%)	P value	Intercept	P value	F-statistic
GrimAge	AVS	0.560	1.160	0.0	0.527	− 0.085	–	11.755
HannumAge	AVS	0.018	10.046	70.1	0.126	− 0.107	0.077	26.587
HorvathAge	AVS	0.897	7.092	0.0	0.693	− 0.005	0.904	20.189
PhenoAge	AVS	0.991	0.850	0.0	0.757	0.009	0.993	18.632
AVS	GrimAge	0.636	13.494	0.0	0.684	0.010	0.667	20.565
AVS	HannumAge	0.157	20.398	26.5	0.542	0.018	0.186	20.958
AVS	HorvathAge	0.339	17.739	9.8	0.879	− 0.004	0.346	20.565
AVS	PhenoAge	0.870	9.930	0.0	0.830	− 0.007	0.887	20.565

ISSN: 1868-7083