Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age

Table 3 Top 10 DMRs associated with vitamin C supplementation

Seqnames	Start	End	Width	# CpGs	Min_smoothed_fdr	Direction	Maxdiff	Meandiff	Overlapping.genes
chr6	31,507,316	31,508,665	1350	14	6.77E−22	HYPO	− 0.020	− 0.008	DDX39B, ATP6V1G2-DDX39B
chr19	35,629,273	35,630,651	1379	17	7.24E−19	HYPO	− 0.027	-0.013	FXYD1, CTD-2527I21.4, LGI4, AC020907.2
chr3	49,057,259	49,058,430	1172	14	1.03E−18	HYPO	− 0.015	− 0.007	NDUFAF3, DALRD3, MIR425, MIR191
chr2	71,133,854	71,134,936	1083	8	2.11E−15	HYPER	0.021	0.013	VAX2
chr6	110,720,501	110,721,629	1129	6	4.63E−15	HYPER	0.061	0.036	DDO
chr8	38,757,532	38,757,859	328	5	9.17E−15	HYPO	− 0.036	− 0.024	NA
chr11	66,233,183	66,234,186	1004	12	1.39E−13	HYPO	− 0.026	− 0.007	MRPL11
chr17	42,081,179	42,082,647	1469	13	5.25E−12	HYPO	− 0.022	− 0.006	NAGS, PYY
chr11	2,153,991	2,154,952	962	10	2.62E−11	HYPER	0.026	0.014	IGF2, INS-IGF2
chr20	57,426,757	57,427,650	894	29	2.89E−11	HYPO	− 0.036	0.006	GNAS

ISSN: 1868-7083