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Table 2 Top 20 DMCs associated with vitamin C supplementation

From: Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age

Probe

CHR

MAPINFO

Feature-CpGisland

Nearest genes

Direction

logFC

P.Value

Adjusted P.Value

cg12095807

14

88,700,366

Body-opensea

KCNK10

HYPER

0.134

9.87E−09

2.96E−03

cg08963132

3

130,064,261

TSS200-shore

COL6A5

HYPO

− 0.152

1.07E−08

2.96E−03

cg24124954

6

31,508,106

Body-shore

DDX39B

HYPO

− 0.210

1.19E−08

2.96E−03

cg06781424

15

51,369,527

Body-opensea

TNFAIP8L3

HYPER

0.108

2.67E−08

4.98E−03

cg20804756

6

31,507,857

Body-shore

DDX39B

HYPO

− 0.181

5.00E−08

6.87E−03

cg00813090

10

75,386,088

IGR-shore

MYOZ1

HYPER

0.178

5.93E−08

6.87E−03

cg15948509

16

1,832,913

TSS200-island

NUBP2

HYPER

0.177

6.45E−08

6.87E−03

cg05522700

7

120,589,681

TSS1500-shore

ING3

HYPO

− 0.281

7.68E−08

7.17E−03

cg01227964

10

92,683,897

IGR-opensea

ANKRD1

HYPER

0.234

1.24E−07

1.03E−02

cg10758716

13

99,184,827

Body-opensea

STK24

HYPO

− 0.140

1.82E−07

1.21E−02

cg01803717

1

8,939,106

TSS1500-island

ENO1

HYPER

0.089

1.99E−07

1.21E−02

cg22378064

10

80,476,116

IGR-opensea

LINC00856

HYPER

0.290

2.06E−07

1.21E−02

cg09585004

2

56,236,485

Body-opensea

CCDC85A

HYPO

− 0.236

2.27E−07

1.21E−02

cg11878331

8

72,469,507

IGR-island

EYA1

HYPER

0.167

2.57E−07

1.21E−02

cg13392861

9

37,914,861

IGR-opensea

SHB

HYPO

− 0.103

2.76E−07

1.21E−02

cg24067803

11

70,653,378

Body-opensea

SHANK2

HYPO

− 0.138

3.23E−07

1.21E−02

cg12691620

1

53,152,081

3'UTR-opensea

COA7

HYPO

− 0.214

3.24E−07

1.21E−02

cg17995273

3

136,936,856

IGR-opensea

IL20RB

HYPO

− 0.154

3.25E−07

1.21E−02

cg10693616

17

7,982,670

Body-island

ALOX12B

HYPO

− 0.280

3.28E−07

1.21E−02

cg01109169

2

71,134,630

Body-island

VAX2

HYPER

0.201

3.78E−07

1.21E−02