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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age

Fig. 3

The majority of buccal DNAm signatures at 5 years are persistent from early life. Out of 457 vitamin C DMCs at 5 years, panel A shows the 365 CpGs with no significant interaction between time and treatment. The axes on the left panel are the vitamin C treatment effect sizes (logFC) at the indicated ages and the ellipses show the correlation (between 0 and 1) of treatment logFC between each pair of timepoints. The right panel is a heatmap of treatment effect sizes in these stable/persistent CpGs with hierarchical clustering. Panel B shows the remaining 92 CpGs with one or more significant interaction between treatment and time, repeating the correlation of logFC between ages in the left panel and heatmap clustering on the right

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Clinical Epigenetics

ISSN: 1868-7083

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