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Table 3 EWAS meta-analysis results between genome-wide DNA methylation and PUFA intake in KORA and LLS

From: Epigenome-wide association study of dietary fatty acid intake

 

Model 1

Model 2

PUFA

CpG

CHR

Position

Gene

Beta

SE

Direction

95% CI

p value

N

Beta

SE

Direction

95% CI

p value

N

DHA

cg19937480

1

45,987,798

PRDX1

2.00E-05

3.70E-06

 + −

1.27E-05

− 2.73E-05

5.80E-08*

1834

1.92E-05

3.90E-06

 +−

1.16E-05

− 2.68E-05

1.19E-06

1834

EPA

cg15951061

7

21,946,025

CDCA7L

2.07E-05

3.9E-06

 +  + 

1.31E-05 -

2.83E-05

1.00E-07*

1834

2.19E-05

4.00E-06

 +  + 

1.41E-05

− 2.97E-05

5.91E-08*

1834

  1. EWAS: Epigenome-wide association study, PUFA, Polyunsaturated fatty acid, CHR: Chromosome, SE: Standard Error, Direction: direction of effect in the individual cohorts, KORA and LLS, 95% CI: 95% Confidence Interval, DHA: Docosahexaenoic acid, EPA: Eicosapentaenoic acid. Model 1: adjusted for age, sex, BMI, smoking, WBC% and technical variables. Model 2: same as Model 1 further adjusted for physical activity, energy intake, estrogen therapy and supplement intake (if applicable). *statistically significant (Bonferroni threshold 1.23 × 10–7)
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Clinical Epigenetics

ISSN: 1868-7083

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