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Table 2 EWAS between genome-wide DNA methylation and PUFA intake in the KORA study

From: Epigenome-wide association study of dietary fatty acid intake

 

Model 1

Model 2

PUFA

CpG

CHR

Position

Gene

Beta

SE

Lower 95% CI

Upper 95% CI

p value

N

Beta

SE

Lower 95% CI

Upper 95% CI

p value

N

DHA

cg19937480

1

45,987,798

PRDX1

2.00E-05

3.69E-06

1.28E-05

2.73E-05

6.98E-08*

1349

1.92E-05

3.95E-06

1.15E-05

2.69E-05

1.24E-06

1349

DPA

cg05041783

11

63,656,223

MARK2

8.43E-05

1.60E-05

5.29E-05

1.16E-04

1.65E-07

1337

9.8E-05

1.81E-05

6.25E-05

1.33E-04

6.75E-08*

1337

  1. EWAS: Epigenome-wide association study, PUFA, Polyunsaturated fatty acid, CHR: Chromosome, SE: Standard Error, 95% CI: 95% Confidence Interval, DHA: Docosahexaenoic acid, DPA: Docosapentaenoic acid. Model 1: adjusted for age, sex, BMI, smoking, WBC% and technical variables. Model 2: same as Model 1 further adjusted for physical activity, energy intake, estrogen therapy and supplement intake (if applicable). *statistically significant (Bonferroni threshold 7.17 × 10–8)
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Clinical Epigenetics

ISSN: 1868-7083

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