Fig. 2

Manhattan plot of meta-EWAS results of EPA Panel A. Manhattan plot of results from meta-analysis of epigenome-wide association studies on EPA using linear regression models adjusting for age, sex, BMI, smoking, WBC% and technical variables. The x-axis shows the chromosomal position, and the y-axis the -log10 p value of the DMP-PUFA association. The horizontal gray line indicates the genome-wide significance threshold at a Bonferroni-corrected p value lower than 0.05 (alpha = 1.23 × 10 − 7). The red dot represents the significant DMP identified in this analysis labeled with the cpg name and its annotated gene name. Panel B. Manhattan plot of results from meta-analysis of epigenome-wide association studies on EPA using linear regression models adjusted for age, sex, BMI, smoking, WBC%, technical variables, physical activity, energy intake, estrogen therapy and PUFA supplement intake