Fig. 1
From: Reduced representative methylome profiling of cell-free DNA for breast cancer detection
A reduced representative methylome profiling method. a Schematic representation of RRMP. b Genome plot for the GBGT1 gene locus compares read coverage between 1-cut RRMP (K562) and public WGBS (K562) and RRBS (SW1353) datasets. Boxes represent reads, and unmethylated (blue) and methylated (red) CpGs are indicated. CpG islands are indicated. c Genome plot for the GBGT1 gene locus shows distribution of 1-cut RRMP reads and MseI targeted sites in both Watson and Crick strand. d, e Plot shows the average coverage depth as a function of distance between the upstream and downstream enzyme recognition sites in both Watson (d) and Crick (e) strand