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Fig. 1 | Clinical Epigenetics

Fig. 1

From: The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications

Fig. 1

The perspectives and relevant mechanisms of this review. Methylation-driven remodeling is intricately associated with the maintenance or alteration of the TME, particularly the TIME. The methylation of tumor suppressor genes (left) or the demethylation of proto-oncogenes (right) is closely linked to the initiation and progression of cancer. The TIME is generally classified into immune-exempt “cold tumors” and inflamed “hot tumors” phenotypes. DNA methylation reprogramming exerts multifaceted regulation on the TIME through its influence on the infiltration, differentiation, secretion of various tumor immune cells (Tregs, B cells, macrophages), vascular genesis (hypoxic microenvironment), metabolism (lipids, mitochondria), and other aspects

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Clinical Epigenetics

ISSN: 1868-7083

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