Fig.2

Landscape of genetic and transcriptional variations of DRGs in LUAD. A, B Summary of the variation patterns observed in 616 patients with LUAD, including the classification and type of genetic variations, SNV classification, frequency of occurrence of mutations in each sample, and the top 10 most frequently mutated genes. C, D Landscape of genetic variations of 616 LUAD patients in TCGA cohort. E CNV amplifications and deletions of DRGs in LUAD patients. F Variations in the gene expression levels of 14 DRGs in tumor samples compared to their normal counterparts. G The circus plot depicted the spatial distribution of CNV in DRGs across 23 chromosomes. H The observed network revealed the interconnections between different DRGs in LUAD. In node connections, red indicates positive correlation, while blue signifies negative correlation. The node's size represents the P-value of the prognosis, its color indicates the gene's risk—purple for high-risk and green for low-risk. **P < 0.01, ***P < 0.001