Table 1 Participant characteristics from pilot study of OPLHIV in Eswatini included in DNA methylation analyses
Variable | Participants (n = 44) |
|---|---|
Age (years) [median (IQR)] | 59 (54, 66) |
Sex | |
Female | 24 (54%) |
Male | 20 (46%) |
Weight, at recent visit (kg) | 75 (66, 87) |
Education | |
None | 5 (11%) |
Primary School Grade 1–7 | 23 (52%) |
Secondary School Form 1–3 | 12 (27%) |
High School Form 4–5 | 4 (9%) |
Years Since HIV Diagnosis (years) | 7 (5, 9) |
Age at HIV Diagnosis (years) | 53 (47, 58) |
Age at ART Initiation (years) | 53 (47, 59) |
ART Duration (years) | 6 (4, 8) |
WHO Clinical Stage 1 of HIV, at recent visit | 40 (91%) |
CD4+ T Cell Count at Enrollment (cell/uL) | 629 (457, 837) |
CD4+ T Cell Count at ART Initiation (cells/uL) | 202 (106, 289) |
Missed ART At Least Once in a Month, answered yes | 9 (21%) |
HIV Viral Load < 200 copies/mL, at recent visit | 40 (91%) |
SF-36 Health Questionnaire (0–100 Scale) | 69 (53, 90) |
Average Servings of Fruits and/or Vegetables, daily | 0.8 (0.6, 1.3) |
Servings of Fruits and/or Vegetables, weekly | 10 (7, 14) |
Eat Processed Food High in Salt, answered always/often | 19 (43%) |
Physical Activity | |
Total Physical Activity, week (min) | 855 (390, 2220) |
Recreational/Leisure Time Physical Activity of ≥ 30 min in a week, answered yes | 2 (5%) |
Smoked Tobacco Ever, answered yes | 16 (36%) |
Estimated Immune Cell Composition (% of Total Composition) | |
CD4+ T Cell | 7% (5, 10) |
CD8+ T Cell | 23% (18, 27) |
Natural Killer Cell | 6% (5, 9) |
B Cell | 8% (5, 9) |
Monocyte | 10% (9, 12) |
Neutrophil | 51% (44, 55) |
Epigenetic Age Metrics | |
Horvath Epigenetic Age (years) | 60 (56, 67) |
Hannum Epigenetic Age (years) | 52 (45, 58) |
PhenoAge Biological Age (years) | 68 (63, 77) |
GrimAge Biological Age (years) | 56 (50, 61) |
DunedinPACE (pace to ref. of 1.0) | 1.2 (1.1, 1.3) |