Fig. 2

Effect sizes for the associations between HIV status variables and epigenetic aging adjusted for lifestyle and quality of life factors. Effect estimates (95% CI) for the change in A Hannum EAA by age at HIV diagnosis, B Hannum EAA by years since HIV diagnosis, and C Hannum EAA by CD4⁺ T cell counts at enrollment. Each plot represents effect estimates for four separate models: Model 1 (Green; covariates: age, sex, education level, past smoking status, and estimated cell-type composition); Model 2 (Orange; Model 1 + weekly dietary servings of fruits/vegetables); Model 3 (Navy; Model 1 + SF-36 questionnaire [perceived quality of life]); Model 4 (Green-Yellow; Model 1 + total physical activity [work-related moderate/vigorous + commuting + leisure/recreational moderate/vigorous activity] Significance taken at p < 0.05, represented by *; p < 0.05 *