Fig. 5
From: YAP represses intestinal inflammation through epigenetic silencing of JMJD3
JMJD3 inhibitor GSK-J4 alleviate DSS-induced mice colitis. A Schematic representation of the DSS protocol used to induce acute colitis in YAPIEC−/− mice, along with GSK-J4 administration. B–E Body weight (B), DAI (C), and colon length (D, E) of mice in the WT, WT + GSK-J4, YAPIEC−/− and YAPIEC−/−+ GSK-J4 groups. (F) H&E-stained sections of colon tissues collected from the WT, WT+ GSK-J4, YAPIEC−/− and YAPIEC−/−+ GSK-J4 groups. G Relative protein expression levels of intestinal barrier protein in the whole colon of the WT, WT+ GSK-J4, YAPIEC−/− and YAPIEC−/−+ GSK-J4 groups. H Relative mRNA expression levels of chemokines in the whole colon of the WT, WT+ GSK-J4, YAPIEC−/− and YAPIEC−/−+ GSK-J4 groups