Fig. 3
From: YAP represses intestinal inflammation through epigenetic silencing of JMJD3
YAP involved in intestinal inflammation via regulating JMJD3. A Boxplot of JMJD3 expression in healthy controls and UC patients (using dataset GSE75214; n = 108). B qPCR analysis of JMJD3 in healthy controls (n = 16) and UC patients (n = 17), respectively. C Relative protein level of JMJD3 in healthy controls and UC patients, respectively. D Relative protein expression of YAP, JMJD3 and H3K27me3 in the siNC, siYAP, siNC+ TNF-a, and siYAP+ TNF-a groups across two cell lines. E Relative protein expression of YAP, JMJD3 and H3K27me3 in the oeNC and oeYAP groups across two cell lines. F The correlation between YAP and JMJD3 in UC patients (using dataset GSE75214; n = 97). G Immunofluorescence analysis of intestinal tissue stained with anti-JMJD3 (green) and anti-YAP (red) antibodies; nuclei were stained with DAPI (blue). H Representative IHC analysis of JMJD3 expression in colonic tissue samples from DSS-treated YAPf/f and YAPIEC−/− mice. Quantitative assessment of JMJD3 expression shown on right