Fig. 2

Heatmap of EBV methylation density in four tumor tissue samples. A Methylation density heatmap of 81 EBV genes annotated with 3497 CpG loci in NPC, EBVaGC, lung LELC and parotid LELC tissues. The redder the color, the higher the methylation density, and the bluer the lower the methylation density. The genes within the red boxed area were relatively hyper-methylated; while, the genes within the blue boxed area were relatively hypo-methylated. B Methylation density heatmap of the most variable loci among these tumor tissues. In the heatmap, the black box indicated the loci with significantly higher or lower methylation levels in the corresponding tumor tissue, compared to other tumor tissues