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Fig. 5 | Clinical Epigenetics

Fig. 5

From: TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy

Fig. 5

Possible pathological mechanisms of retinal neovascularization and FVM proliferation in patients with PDR. TET2 overexpression in retinal endothelial cells is increased in the diabetic environment, prompting TET2 to act on the CpG island, reducing the methylation level of the ECM1 gene promoter. The gene of ECM1 opens and allows transcription, thereby increasing the expression level. Through a series of subsequent pathways, ECM1 promotes retinal neovascularization and FVM proliferation, ultimately leading to the development of PDR

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Clinical Epigenetics

ISSN: 1868-7083

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