Fig. 1

MC180295 enzymatic/growth inhibition and pharmacokinetics. A In vitro activity (IC50 values) of MC180295 against a panel of CDKs. B MC180295 IC50 values against 46 cell lines from 6 different cancer types. C Pharmacokinetic analyses after oral or IV administration of low-dose (1 mg/kg IV or 2.5 mg/kg oral) MC180295 to mice. D Pharmacokinetic analyses after IP administration of 10 mg/kg MC180295 to mice. E Pharmacokinetic analyses after IV administration of 1 mg/kg MC180295 to rats