Fig. 1

A illustrates the distribution of mean coverage per sample within our data, color-coded by group (NC in dark gray, HFA in light gray). B shows the correlation between mean coverage and DNA concentration across samples, indicating a positive association. C and D give the coverage across the genomic region (with CpG positions indicated by black dots) of the guide RNA derived fragments chr3: 8,761,480—8,749,344 (C) and chr3: 8,770,937–8,763,067 (D). In D, the regulatory relevant genomic regions (also displaying a high CpG density) are indicated by dashed lines (blue–Exon 3, red–MT2 area)