Fig. 7
From: Histone acetylation: a key determinant of acquired cisplatin resistance in cancer
Schematic representation highlighting the molecular alterations in cisplatin resistant model. Cisplatin-resistant cells display more activation of PI3K signaling, Acetyl-CoA production and histone hyperacetylation. The occupancy of histone acetylation marks on the promoter of genes related to PI3K subunits and glycolysis in resistant cells indicates their importance. Inhibiting glycolysis using 2-DG or PI3K signaling may imporove therapeutic outcome in terms of reduces tumor growth