Fig. 3
From: Histone acetylation: a key determinant of acquired cisplatin resistance in cancer
Alteration in histone modifying enzymes and their activity. A, B Bar graphs representing qPCR analysis for HAT & HDAC genes in HeLa and HepG2 cisplatin resistant model systems. C Estimation of HAT activity in cisplatin resistant cell lines. D Investigation of HDAC activity in resistant cells. E Assessment of acetyl-CoA levels in cisplatin-resistant cells. F Western blot analysis for histone lysine acetylation in in vitro cisplatin resistant models. G Western blot analysis for histone lysine acetylation in in vivo HeLa cisplatin resistant model. Error bar represents mean ± S.D from 3 replicates. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001