Fig. 8
From: In-silico guided chemical exploration of KDM4A fragments hits
2-Carbamoylpyridine-4-carboxylic acid derivatives 6b and 6c. Dose–response curve (left), BLI sensorgram (middle), and binding pose (right) for compound 6b A, and compound 6c B. In the binding pose, H-bond, salt-bridge, and pi-pi interactions are depicted as yellow, violet, green and blue dashed lines, respectively. Fitting of IC50 and BLI curves was performed as already reported in Fig. 3