Table 3 Pathways significantly enriched in hypermethylated DMCs in the LGA group according to WikiPathways [36]
Term | Overlap | P value | Adjusted P value | Odds ratio | Combined score | Genes |
|---|---|---|---|---|---|---|
Heart Development WP1591 | 8/44 | 5.15E-05 | 0.015 | 7.071 | 69.826 | TBX1;FOXC1;SHH;BMP2;HAND2;FOXH1;TBX5;TBX2 |
Development of ureteric collection system WP5053 | 8/47 | 8.42E-05 | 0.015 | 6.526 | 61.233 | FOXC1;SHH;WT1;SIX2;LHX1;GATA3;FAT4;HOXD11 |
LncRNA involvement in canonical Wnt signaling and colorectal cancer WP4258 | 11/94 | 1.47E-04 | 0.018 | 4.228 | 37.300 | APC2;TFAP2A;WNT10A;WNT2B;MYC;FZD7;TCF7;DVL1;FZD10;NOTUM;NKD1 |
Breast cancer pathway WP4262 | 14/154 | 3.00E-04 | 0.022 | 3.196 | 25.934 | APC2;WNT10A;CDKN1A;WNT2B;NOTCH4;FZD7;TCF7;FZD10;FGF17;DLL4;MYC;DVL1;ERBB2;PGR |
ncRNAs involved in Wnt signaling in hepatocellular carcinoma WP4336 | 10/86 | 3.08E-04 | 0.022 | 4.192 | 33.893 | WNT10A;WNT2B;MYC;FZD7;TCF7;DVL1;FZD10;NOTUM;KLF4;NKD1 |
Somatic sex determination WP4814 | 4/14 | 6.97E-04 | 0.043 | 12.662 | 92.038 | NR5A1;WT1;AMH;PTGDS |
Melatonin metabolism and effects WP3298 | 6/37 | 8.58E-04 | 0.045 | 6.140 | 43.356 | ACHE;MTNR1A;AANAT;CYP1B1;APOE;FOXO1 |