Fig. 1

Identification of DMCs in LGA newborns. (A) Distribution of DMCs represented as the distance to the closest TSS, shown in 500 bp bins. Red bars denote the number of hypermethylated DMCs per bin, and blue bars denote hypomethylated DMCs per bin. (B) Enrichment analysis of the Gene Ontology (GO) category Biological Process (BP) of all hypermethylated DMCs with nominal p < 0.05. Only BPs with corrected p < 0.05 are shown. (C) Gene networks of selected BPs: Norepinephrine, Kidney Development and Cardiovascular Development. The methylation difference between LGA and AGA is shown as a graded color scale, where white is no change and red is hypermethylation. Genes (nodes) are shown either as circles or diamonds, where circles are those showing transcriptional activity according to GO regulation of transcription, DNA-templated (GO:0006355). Edges (connections/lines between nodes) represent co-expression, pathways, colocalization, shared protein domains or physical interactions between the two genes/proteins in the network according to GeneMANIA