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Table 2 Mediation analysis of gene expression in the association between DNA methylation and asthma severity and lung function measure (FEV1) in the discovery BECs dataset

From: Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function

CpG

Gene

Total effect

Direct effect (DE)

Mediational effect (ME)

β (95% CI)

P value

β (95% CI)

P value

β (95% CI)

P value

Mediation proportion

Asthma severity association

        

cg17945560

TINAGL1

0.34 (0.06, 0.59)

0.016

0.076 (− 0.15, 0.28)

0.52

0.26 (0.09, 0.44)

2E−16

77.5

cg01975495

SERPINE1

0.69 (0.36, 0.99)

2E−16

0.57 (0.24, 0.88)

2E−16

0.12 (0.03, 0.25)

0.004

17.3

cg14015211

TLR5

0.314 (0.21, 0.43)

2E−16

0.21 (0.07, 0.35)

0.008

0.106 (0.04, 0.191)

0.004

33.77

cg26639146

CD9

− 0.29 (− 0.5, − 0.06)

0.016

− 0.18 (− 0.38, 0.09)

0.17

− 0.10 (− 0.25, − 0.031)

0.002

36.24

cg10290200

FLNC

− 0.20 (− 0.3, − 0.1)

2E−16

− 0.15 (− 0.26, − 0.03)

0.006

− 0.05 (− 0.11, 01)

0.06

26.69

cg25477769

HNF1A

0.57 (0.203, 0.93)

0.002

0.39 (− 0.02, 0.82)

0.068

0.18 (− 0.02, 0.391)

0.08

31.18

cg21385480

LRIG1

0.41 (0.281, 0.55)

2E−16

0.3 (0.13, 0.45)

2E−16

0.12 (0.03, 0.221)

0.002

27.99

cg10528482

SLC9A3

0.28 (0.183, 0.38)

2E−16

0.2 (0.08, 0.31)

2E−16

0.08 (0.02, 0.141)

0.002

27.97

Lung function association

        

g17945560

TINAGL1

− 0.27 (− 0.53, 0.01)

0.06

− 0.11 (− 0.36, 0.13)

0.07

− 0.17 (− 0.27, − 0.06)

2E−16

61.2

cg01975495

SERPINE1

− 0.61 (− 0.84, − 0.38)

2E−16

− 0.55 (− 0.76, − 0.32)

2E−16

− 0.06 (− 0.15, 0.01)

0.13

9.08

cg14015211

TLR5

− 0.41 (− 0.56, − 0.27)

2E−16

− 0.27 (− 0.43, − 0.12)

2E−16

− 0.14 (− 0.26, − 0.03)

0.022

34.78

cg26639146

CD9

0.34 (0.018–0.63)

0.046

0.25 (− 0.18, 0.55)

0.218

0.09 (0.003, 0.33)

0.034

25.44

cg10290200

FLNC

0.22 (0.08–0.36)

0.006

0.13 (− 0.04, 0.29)

0.154

0.09 (0.004, 0.17)

0.036

42.72

cg25477769

HNF1A

− 0.65 (− 1.18, − 0.11)

0.028

− 0.47 (− 1.07, 0.16)

0.162

− 0.18 (− 0.43, 0.05)

0.124

27.8

cg21385480

LRIG1

− 0.37 (− 0.58, − 0.13)

0.002

− 0.41 (− 0.66, − 0.09)

0.006

0.04 (− 0.12, 0.16)

0.614

10.11

cg10528482

SLC9A3

− 0.25 (− 0.41, − 0.09)

0.002

− 0.18 (− 0.35, − 0.01)

0.044

− 0.07 (− 0.16, 0.01)

0.076

28.5

  1. ME denotes causal mediational effect (indirect effect of each CpG on asthma severity/FEV1 that goes through mediating gene). The values in bold show genes that are significantly mediating the DNA methylation effect on asthma severity/FEV1 association
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Clinical Epigenetics

ISSN: 1868-7083

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