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Table 7 Correlation of HTR2A methylation in circulating blood cells between birth, childhood (7 years) and adolescence (15 years) in subjects from ARIES cohort (N = 808)

From: Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence

Region

cg IDa

ID#b

Birth versus 7 year

Birth versus 15 year

7 year versus 15 year

rsc

p value

rsc

p value

rs c

p value

Promoter

cg09394608

/

0.11

0.001

0.13

 < 0.0001

0.08

0.019

cg07075299

/

0.10

0.005

0.11

0.002

0.19

 < 0.0001

cg05506829

/

0.49

 < 0.0001

0.47

 < 0.0001

0.58

 < 0.0001

cg23881368

/

0.54

 < 0.0001

0.51

 < 0.0001

0.62

 < 0.0001

cg24118521

/

0.52

 < 0.0001

0.45

 < 0.0001

0.63

 < 0.0001

cg15692052

/

0.46

 < 0.0001

0.40

 < 0.0001

0.46

 < 0.0001

cg18200810

/

0.53

 < 0.0001

0.46

 < 0.0001

0.64

 < 0.0001

cg24320398

/

0.38

 < 0.0001

0.37

 < 0.0001

0.56

 < 0.0001

cg09798090

/

0.33

 < 0.0001

0.32

 < 0.0001

0.50

 < 0.0001

cg06020661

/

0.27

 < 0.0001

0.23

 < 0.0001

0.41

 < 0.0001

cg01620540

/

0.03

0.474

0.01

0.851

0.11

0.003

cg01192538

/

0.08

0.029

0.05

0.149

0.09

0.007

cg02027079

1

0.29

 < 0.0001

0.28

 < 0.0001

0.30

 < 0.0001

cg10323433

/

0.10

0.004

0.11

0.002

0.21

 < 0.0001

cg27068143

2

0.13

0.0002

0.11

0.001

0.28

 < 0.0001

Exon 1

cg11514288

/

0.16

 < 0.0001

0.18

 < 0.0001

0.26

 < 0.0001

cg09361691

/

0.21

 < 0.0001

0.19

 < 0.0001

0.23

 < 0.0001

cg16188532

/

0.19

 < 0.0001

0.14

 < 0.0001

0.19

 < 0.0001

cg06476131

/

0.23

 < 0.0001

0.12

0.001

0.20

 < 0.0001

cg02250787

/

0.15

 < 0.0001

0.14

 < 0.0001

0.24

 < 0.0001

cg15894389

/

0.24

 < 0.0001

0.21

 < 0.0001

0.38

 < 0.0001

Intron 1

cg20102280

/

0.08

0.022

0.04

0.306

0.25

 < 0.0001

Exon 2

cg12089079

/

0.11

0.002

0.09

0.007

0.15

 < 0.0001

cg00308665

/

0.16

 < 0.0001

0.10

0.004

0.28

 < 0.0001

Intron 2

cg14059288

/

0.04

0.253

0.05

0.156

− 0.02

0.648

cg12367389

/

0.06

0.066

0.09

0.013

0.09

0.015

Exon 4

cg26950475

/

0.08

0.025

0.07

0.057

0.04

0.206

  1. Significant correlations are shown in bold
  2. aIllumina ID of CpG sites
  3. bID of CpG sites according to Fig. 1 (sites analyzed in PlaNS cohort)
  4. cSpearman’s correlation coefficient
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Clinical Epigenetics

ISSN: 1868-7083

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