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Table 6 Correlation of SLC6A4 methylation in circulating blood cells between birth, childhood (7 years) and adolescence (15 years) in subjects from ARIES cohort (N = 808)

From: Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence

Region

cg IDa

ID b

Birth versus 7 year

Birth versus 15 year

7 year versus 15 year

rs c

p value

rs c

p value

rs c

p value

Promoter

cg12074493

/

− 0.02

0.487

− 0.02

0.653

0.05

0.135

cg06841846

/

− 0.04

0.253

0.02

0.611

− 0.01

0.727

cg18584905

/

0.02

0.658

− 0.01

0.698

0.05

0.188

cg27569822

/

− 0.04

0.305

0.02

0.628

− 0.01

0.749

cg10901968

/

0.03

0.444

− 0.01

0.821

0.07

0.035

cg26741280

/

0.00

0.939

0.02

0.544

0.07

0.054

cg25725890

/

0.09

0.009

0.04

0.237

0.04

0.212

cg05016953

/

0.03

0.470

0.12

0.001

0.10

0.005

Exon 1

cg14692377

/

0.04

0.246

0.09

0.009

0.10

0.005

Intron 1

cg03363743

10

0.25

 < 0.0001

0.20

 < 0.0001

0.21

 < 0.0001

cg22584138

14

0.35

 < 0.0001

0.35

 < 0.0001

0.37

 < 0.0001

cg05951817

/

0.33

 < 0.0001

0.24

 < 0.0001

0.27

 < 0.0001

cg26126367

/

0.07

0.052

0.02

0.479

0.09

0.014

Intron 2

cg01330016

/

− 0.02

0.665

0.04

0.261

− 0.04

0.254

Intron 3

cg24984698

/

0.02

0.522

0.04

0.304

0.11

0.002

Exon 15

cg20592995

/

0.04

0.316

0.06

0.073

0.03

0.376

  1. Significant correlations are shown in bold
  2. a Illumina ID of CpG sites
  3. b ID of CpG sites according to Fig. 1 (sites analyzed in PlaNS cohort)
  4. c Spearman’s correlation coefficient