Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence

Table 5 Hierarchical linear regression analysis of maternal metabolic parameters as predictors of cord blood methylation of CpG site #2 (-1224) in HTR2A

Step	Variable	B	SE (B)	p (B)	R²	p (R²)	ΔR²	p (ΔR²)
1	Neonatal sex	− 1.32	0.44	0.003	0.042	0.003
2	Neonatal sex	− 1.28	0.45	0.005	0.045	0.010	0.003	0.451
2	pBMI	− 0.03	0.04	0.451	0.045	0.010	0.003	0.451
3	Neonatal sex	− 1.27	0.45	0.005	0.045	0.026	< 0.001	0.782
	pBMI	− 0.03	0.04	0.424
	GWG	− 0.01	0.04	0.782
4	Neonatal sex	− 1.27	0.45	0.005	0.047	0.050	0.001	0.620
	pBMI	− 0.03	0.04	0.504
	GWG	− 0.02	0.04	0.716
	GTS	− 0.23	0.47	0.620
5	Neonatal sex	− 1.21	0.47	0.010	0.066	0.062	0.019	0.264
	pBMI	− 0.02	0.04	0.623
	GWG	0.00	0.04	0.946
	GTS	− 0.16	0.48	0.734
	Parity	0.70	0.47	0.140
	Maternal age	− 0.01	0.05	0.868
	Birth weight	0.00	0.00	0.175

ISSN: 1868-7083