Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence

Table 4 Hierarchical linear regression analysis of maternal metabolic parameters as predictors of cord blood methylation of CpG site #1 (-1665) in HTR2A

Step	Variable	B	SE (B)	p (B)	R²	p (R²)	ΔR²	p (ΔR²)
1	Neonatal sex	1.55	1.11	0.166	0.010	0.166
2	Neonatal sex	1.67	1.12	0.137	0.014	0.241	0.005	0.334
2	pBMI	− 0.09	0.09	0.334	0.014	0.241	0.005	0.334
3	Neonatal sex	1.47	1.12	0.189	0.036	0.063	0.022	0.036
	pBMI	− 0.03	0.09	0.725
	GWG	0.21	0.10	0.036
4	Neonatal sex	1.47	1.12	0.190	0.036	0.119	< 0.001	0.791
	pBMI	− 0.03	0.10	0.776
	GWG	0.21	0.10	0.044
	GTS	− 0.31	1.17	0.791
5	Neonatal sex	1.56	1.16	0.180	0.056	0.125	0.020	0.260
	pBMI	− 0.01	0.10	0.935
	GWG	0.25	0.11	0.017
	GTS	0.00	1.19	0.999
	Parity	1.34	1.18	0.258
	Maternal age	− 0.11	0.12	0.366
	Birth weight	0.00	0.00	0.166

ISSN: 1868-7083