Fig. 7
KDM4B promotes cell proliferation through the miR-181d-5p/SCFFBXL3+CRY2/MYC axis. A miR-181d-5p was detected by microRNA detection kits. B MTT assays were used to evaluate the proliferative capacity of GBM cells after miR-181d-5p was transfected. C Plate colony formation assays were used to evaluate the colony formation ability of GBM cells after miR-181d-5p was transfected. D Western blots were applied to measure the protein levels of KDM4B, FBXL3, CRY2, MYC, cyclin B1, GAPDH, H3K9me3, and H3 after miR-181d-5p was transfected. E The expression of miR-181d-5p was measured after restoration of wild-type KDM4B or mutant KDM4B. *p < 0.05, **p < 0.01, ***p < 0.001