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Table 3 Associations between PM2.5 exposure and individual placental types estimated using Beta regressions

From: DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study

Effect of PM2.5

Syncytiotrophoblasts

Trophoblasts

Stromal

Endothelial

Hofbauer

nRBC

Overall

T1

 − 0.019 (− 0.080, 0.041)

0.128 (− 0.008, 0.264)

 − 0.023 (− 0.071, 0.025)

0.032 (− 0.029, 0.092)

 − 0.024 (− 0.223, 0.175)

0.001 (− 0.055, 0.056)

T2

0.018 (− 0.026, 0.061)

 − 0.02 (− 0.119, 0.079)

 − 0.027 (− 0.061, 0.007)

 − 0.029 (− 0.073, 0.015)

0.105 (− 0.038, 0.248)

0.027 (− 0.013, 0.067)

T3

 − 0.010 (− 0.062, 0.042)

 − 0.033 (− 0.153, 0.088)

0.026 (− 0.015, 0.066)

0 (− 0.052, 0.052)

 − 0.042 (− 0.212, 0.128)

 − 0.023 (− 0.070, 0.025)

Females

T1

0.027 (− 0.060, 0.115)

0.027 (− 0.162, 0.217)

 − 0.065 (− 0.128, − 0.001)

 − 0.002 (− 0.077, 0.073)

 − 0.221 (− 0.502, 0.059)

 − 0.001 (− 0.074, 0.072)

T2

0.055 (− 0.010, 0.120)

 − 0.109 (− 0.251, 0.033)

 − 0.054 (− 0.102, − 0.007)

 − 0.033 (− 0.089, 0.024)

0.079 (− 0.128, 0.286)

0.032 (− 0.023, 0.087)

T3

 − 0.025 (− 0.107, 0.057)

 − 0.021 (− 0.203, 0.162)

0.028 (− 0.031, 0.087)

0.028 (− 0.043, 0.098)

 − 0.008 (− 0.271, 0.254)

 − 0.088 (− 0.159, − 0.017)

Males

T1

 − 0.078 (− 0.162, 0.005)

0.273 (0.081, 0.465)

0.037 (− 0.034, 0.107)

0.056 (− 0.039, 0.151)

0.221 (− 0.063, 0.505)

0 (− 0.081, 0.081)

T2

 − 0.030 (− 0.088, 0.028)

0.069 (− 0.070, 0.207)

0.009 (− 0.040, 0.059)

 − 0.021 (− 0.087, 0.045)

0.173 (− 0.027, 0.374)

0.024 (− 0.032, 0.081)

T3

0.023 (− 0.042, 0.089)

 − 0.088 (− 0.247, 0.072)

0.012 (− 0.043, 0.066)

 − 0.027 (− 0.102, 0.049)

 − 0.131 (− 0.358, 0.096)

0.025 (− 0.037, 0.088)

  1. All estimates are reported in log-odds scale and rounded to the third decimal point, in parenthesis are the 95% bootstrap confidence intervals. p-values < 0.05 are highlighted in bold. T1: 1st trimester, T2: 2nd trimester, T3: 3rd trimester, nRBC: nucleated red blood cells