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Table 2 Composition analyses between trimester-average PM2.5 and placental cell types

From: DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study

Effect of PM2.5

Syncytiotrophoblasts

Trophoblasts

Stromal

Endothelial

Hofbauer

nRBC

p-value*

Overall

T1

 − 0.013 (− 0.034, 0.007)

0.015 (− 0.002, 0.035)

 − 0.004 (− 0.010, 0.002)

0.002 (− 0.003, 0.007)

0 (− 0.002, 0.002)

0 (− 0.002, 0.002)

0.115

T2

0.005 (− 0.007, 0.017)

 − 0.002 (− 0.011 0.007)

 − 0.003 (− 0.008, 0.002)

 − 0.003 (− 0.007, 0.002)

0.001 (0, 0.003)

0.001 (0, 0.003)

0.067

T3

0.002 (− 0.015, 0.016)

 − 0.005 (− 0.018, 0.008)

0.004 (− 0.002, 0.009)

0 (− 0.005, 0.006)

0 (− 0.001, 0.001)

0 (− 0.003, 0.001)

0.162

Female

T1

0.005 (− 0.027, 0.036)

0.003 (− 0.020, 0.032)

 − 0.007 (− 0.017, 0.002)

0 (− 0.008, 0.008)

 − 0.001 (− 0.001, 0.001)

0 (− 0.003, 0.003)

0.160

T2

0.017 (− 0.001, 0.033)

 − 0.010 (− 0.023, 0.004)

 − 0.006 (− 0.012, 0.002)

 − 0.003 (− 0.009, 0.003)

0 (− 0.001, 0.002)

0.001 (− 0.001, 0.004)

0.040

T3

 − 0.002 (− 0.030, 0.019)

 − 0.003 (− 0.024, 0.021)

0.004 (− 0.004, 0.013)

0.004 (− 0.003, 0.011)

0 (− 0.001, 0.002)

 − 0.003 (− 0.005, − 0.001)

0.049

Males

T1

 − 0.037 (− 0.066, − 0.012)

0.033 (0.009, 0.064)

0.001 (− 0.009, 0.009)

0.003 (− 0.006, 0.011)

0.002 (− 0.002, 0.011)

 − 0.001 (− 0.003, 0.002)

0.033

T2

 − 0.009 (− 0.027, 0.009)

0.006 (− 0.007, 0.020)

0.001 (− 0.007, 0.008)

 − 0.002 (− 0.009, 0.005)

0.003 (− 0.001, 0.011)

0.001 (− 0.001, 0.003)

0.117

T3

0.010 (− 0.011, 0.028)

 − 0.010 (− 0.023, 0.007)

0.002 (− 0.005, 0.010)

 − 0.002 (− 0.009, 0.005)

 − 0.001 (− 0.003, 0.002)

0.001 (− 0.001, 0.004)

0.131

  1. *Overall effects on cell-type composition p-value calculated based on the median F-statistic across 1000 bootstrap samples. In parenthesis are the 95% bootstrap confidence intervals. Significant results are highlighted in bold. T1: 1st trimester, T2: 2nd trimester, T3: 3rd trimester, nRBC: nucleated red blood cells