Fig. 6
DMP analysis of sex specificity in the Central and Yakutia regions. A Manhattan plot for the distribution of adjusted p values of sex-specific CpGs distributed by location in chromosomes for the Central region. B Volcano plot of limma results for all CpGs in the Central region, hypermethylated in females CpGs are highlighted in pink and hypermethylated in males CpGs are highlighted in light blue. C Examples of the sex-specific DMPs distribution for the Central region: top—hypermethylated in females; bottom—hypermethylated in males. D Manhattan plot for the distribution of adjusted p values of sex-specific CpGs distributed by location in chromosomes for the Yakutia region. E Volcano plot of limma results for all CpGs in the Yakutia region, hypermethylated in females CpGs are highlighted in red and hypermethylated in males CpGs are highlighted in dark blue. F Examples of the sex-specific DMPs distribution for the Yakutia region: top—hypermethylated in females; bottom—hypermethylated in males. G UpSet plot showing the intersections of the Top-1000 most statistically significant sex-specific CpGs in the Central and Yakutia regions with the lists of sex-specific CpGs from other published studies. Each column corresponds to the intersection of all lists. The sum of all elements in a row is the total value of the elements in the selected CpG list. (This number is given on the left bar plot: 395 for Grant et al. [44], 417 for Inoshita, et al. [97], 235 for McCarthy et al. [98], 1000 for both our sex-specific CpG lists.) All subsets that include common elements of sex-specific lists for the Central and Yakutia regions from this study are highlighted in red. Yellow indicates subsets of CpGs common to the three sets: sex-specific in Central, sex-specific in Yakutia, and from Grant et al. [44]. Blue indicates subsets of CpGs common to the two sets: sex-specific in Central and Grant et al. [44] (without Yakutia). Green indicates subsets of CpGs common to the two sets: sex-specific in Yakutia and Grant et al. [44] (without Central)