Fig. 2

DMP analysis (limma) of regional specificity. A Manhattan plot for the distribution of corrected p values of region-specific CpGs distributed by location in chromosomes; B Volcano plot of limma results for all CpGs. Hypermethylated CpGs in the Central region are highlighted in yellow, and hypermethylated CpGs in Yakutia are highlighted in gray. The two most significant CpGs are highlighted in the plot; the distributions of methylation levels between regions are shown in C cg04944491 (SMYD3 gene) and D cg24649109 (MYO5C gene). The solid line on the boxplot corresponds to the median value; the dotted line corresponds to the mean value