Fig. 4
From: Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Box plots showing TERT RNA expression after ASEE in Hep-G2 and A-549. A TERT RNA expression shown as log2[CPM] values in untreated Hep-G2 and Hep-G2 transfected with different sgRNAs. Purple and blue color corresponds to TERT sgRNA targeting the mutated (C228T-mut) and wildtype (C228T-wt) allele at C228T position respectively. B TERT RNA expression shown as log2[CPM] values in untreated A-549 and A-549 transfected with different sgRNAs. Orange color corresponds to TERT sgRNA targeting the alternative G allele at rs2853669 SNP position (rs2853669-alt). A, B Yellow color corresponds to untreated cells (UT) and light green color corresponds to cells transfected with scrambled sgRNA