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Fig. 3 | Clinical Epigenetics

Fig. 3

From: A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide

Fig. 3

A Heatmap display of histone PTM levels in PPGL patient tissues. L/H (light/heavy) relative abundances ratios were obtained using a spike-in strategy (light channel: sample, heavy channel: spike-in standard) and were normalised over the average ratios across samples. The grey colour indicates peptides that were not quantified. Right panel: Modified peptides were compared in samples belonging to Cluster 1A or other tumour classes by multiple t test. The red colour indicates a significant increase (FDR < 0.05) in Cluster 1A, and the blue colour indicates a significant decrease. B PCA analysis based on quantitative histone PTM data obtained from the samples shown in A. C Boxplot display of the data shown in A, for selected PTMs. *** FDR < 0.001 by multiple unpaired t test

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Clinical Epigenetics

ISSN: 1868-7083

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