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Table 1 Clinical characteristics of surviving and deceased COVID-19 patients following hospitalization

From: Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

 

COVID-19 Survived (N = 68)

COVID-19 Died

(N = 19)

Controls

(N = 21)

Age

47 (41–53.5)

58 (52.5–63.5)

40 (34–45)

Epigenetic age

   

 DNAmAge

52.4 (46.7–60.1)

57.7 (54.5–63)

43.5 (40.4–52.1)

 DNAmAgeHannum

38.2 (33.3–45.1)

44.7 (39.9–51.4)

25.6 (23.5–33.3)

 DNAmPhenoAge

40.6 (34.3–50.1)

50.6 (44–58.8)

27.6 (20.6–38.1)

 DNAmAgeSkinBloodClock

46.5 (40.7–56.2)

54.4 (50.3–61)

38.6 (35.1–46.2)

 DNAmGrimAge

55.5 (50.8–61.2)

63.8 (60.3–68.7)

46 (39.4–52.7)

 Gender (male)

63 (93%)

19 (100%)

21 (100%)

 BMI (kg/m2)

27.4 (25.3–31.4)

25.7 (24.4–29.9)

28.7 (26–30.1)

 Duration of MV (days)

7 (4–13.5)

20 (14.5–26.5)

-

 ICU LoS (days)

14 (9.7–26.2)

24 (15–30.5)

-

 Hospital LoS (days)

30 (22–46)

25 (17–35)

-

 ECMO

7 (10%)

4 (21%)

 

 Nosocomial infections

35 (51.5%)

15 (78.9%)

-

 Convalescent plasma therapy

21 (30.9%)

6 (31.6%)

-

Diabetes status

   

 Non diabetes

34 (50%)

12 (63.2%)

–

 Pre-diabetes

2 (3%)

1 (5.3%)

–

 Diabetes

32 (47%)

6 (31.6%)

–

 Hypertension

29 (42.9%)

9 (47.4%)

–

 Coronary artery disease

4 (5.9%)

1 (5.3%)

–

 Chronic kidney failure

5 (7.4%)

2 (10.5%)

–

 Chronic heart failure

1 (1.5%)

0

–

  1. Data are represented as number of cases (%) per each category for categorical variables and as median (1st–3rd quartile) for continuous variables
  2. ICU Intensive care unit, LoS Length of stay, MV Mechanical ventilation. ECMO Extracorporeal membrane oxygenation