Fig. 4

Dynamic change in epigenetic age acceleration in survived versus deceased COVID-19 patients between inclusion and the end of follow-up (FU) timepoint. Dynamic change in DNAm age acceleration measured via the a. Horvath and b. PhenoAge clocks in the peripheral blood from 50 surviving versus 14 deceased COVID-19 patients. The y-axis denotes the epigenetic age acceleration. p value is shown above the corresponding line and compares EAA between the end of follow-up and inclusion (EAA end of follow-up—EAA inclusion) in the survived versus deceased group. In the box plots, the lower and upper hinges indicate the 25th and 75th percentiles and the black line within the box represents the median