DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Clinical Epigenetics

Table 3 Univariate and sex differences twin modelling of 14 CpG sites meeting the twin modelling assumptions

CpG name	MZ twin correlation	DZ twin correlation	Mean	SD	Best model	Heritability [95% CI]	Shared environment [95% CI]	Unique environment [95% CI]	Sex differences identified
cg02614024	0.69	0.29	0.19	0.06	AE	0.67 [0.61, 0.72]	–	0.33 [0.28, 0.39]	Unstandardised genetic and environmental variance components
cg03115019	0.96	0.50	0.85	0.11	AE	0.96 [0.95, NA]	–	0.04 [NA, 0.05]	None
cg03551401	0.55	0.33	0.49	0.07	AE	0.51 [0.42, 0.58]	–	0.49 [0.42, 0.58]	Mean structure
cg05038881	0.83	0.44	0.44	0.06	AE	0.84 [NA, NA]	–	0.16 [0.13, NA]	Mean structure
cg06096446	0.89	0.48	0.70	0.09	AE	0.88 [0.86, 0.90]	–	0.12 [0.10, 0.14]	Mean structure
cg08883485	0.94	0.52	0.46	0.08	AE	0.94 [0.92, NA]	–	0.06 [NA, 0.08]	Mean structure
cg09179916	0.61	0.18	0.92	0.06	AE	0.60 [0.53, 0.67]	–	0.40 [0.33, 0.47]	Mean Structure, unstandardised genetic and environmental variance components
cg15030014	0.89	0.78	0.89	0.06	ACE	0.24 [0.17, 0.33]	0.68 [NA, 0.75]	0.08 [0.07, 0.10]	Unstandardised genetic variance component and total phenotypic variance
cg16198723	0.79	0.36	0.60	0.05	AE	0.78 [0.73, NA]	–	0.22 [NA, 0.27]	None
cg17382841	0.61	0.28	0.80	0.07	AE	0.64 [0.56, 0.70]	–	0.36 [0.30, 0.44]	Mean structure
cg18223453	0.81	0.48	0.71	0.05	AE	0.77 [0.72, 0.81]	–	0.23 [0.19, 0.28]	Mean structure
cg22325292	0.98	0.53	0.73	0.19	AE	0.98 [0.97, 0.99]	–	0.02 [NA, 0.03]	None
cg24786174	0.97	0.55	0.53	0.14	AE	0.97 [0.96, NA]	–	0.03 [NA, 0.04]	None
cg25614726	0.77	0.42	0.39	0.05	AE	0.78 [0.74, NA]	–	0.22 [0.19, 0.26]	Mean structure

Best twin model, standardised variance components and potential identified sex differences are shown

ISSN: 1868-7083