Original model and CpG ID | Individual platform effect size (450 K; EPIC) | Standardised effect size* | P value | Q p value‡ | Chr | Gene | Mean (M)†| Mean (F)†| Wilcoxon two-sample test (p)§ |
---|---|---|---|---|---|---|---|---|---|
PDS-12 | |||||||||
cg15030014 | − 0.025; − 0.037 | − 0.175 | 2.85E−07 | 1.000 | 7 | C7orf20 | 0.886 | 0.890 | 1.000 |
cg25614726 | − 0.023; − 0.013 | − 0.169 | 7.61E−07 | 1.000 | 1 | APITD1 | 0.378 | 0.399 | 2.31E−12 |
cg08273672 | − 0.01; − 0.01 | − 0.161 | 2.59E−06 | 1.000 | 4 | UCHL1 | 0.754 | 0.760 | 0.131 |
cg05038881 | − 0.026; − 0.004 | − 0.161 | 2.65E−06 | 1.000 | 1 | APITD1 | 0.430 | 0.451 | 3.32E−09 |
cg26027669 | 0.014; 0.012 | 0.159 | 3.38E−06 | 1.000 | 1 | GFI1 | 0.054 | 0.048 | 9.03E−14 |
cg22064581 | 0.004; − 0.001 | 0.156 | 5.30E−06 | 1.000 | 6 |  | 0.032 | 0.031 | 1.000 |
cg08091771 | − 0.012; − 0.011 | − 0.156 | 5.57E−06 | 1.000 | 3 | PTPRG | 0.705 | 0.708 | 1.000 |
cg26489369 | − 0.009; − 0.002 | − 0.155 | 6.19E−06 | 1.000 | 6 | HLA-DQA2 | 0.950 | 0.952 | 0.228 |
cg06993494 | − 0.009; − 0.017 | − 0.153 | 8.26E−06 | 1.000 | 11 | OR5A1 | 0.966 | 0.967 | 0.132 |
PDS-12—Males | |||||||||
cg25801636 | 0.009; 0.037 | 0.245 | 8.46E−07 | 0.007 | 2 |  | 0.949 | 0.949 | 1.000 |
cg13653963 | 0.003; 0.018 | 0.242 | 9.10E−07 | 0.001 | 9 | C9orf98 | 0.965 | 0.967 | 1.11E−04 |
cg14609721 | 0.015; − 0.005 | 0.249 | 1.04E−06 | 0.750 | 1 | DEPDC1 | 0.019 | 0.018 | 0.098 |
cg03468249 | 0.008; 0 | 0.250 | 1.16E−06 | 0.932 | 2 |  | 0.026 | 0.025 | 1.000 |
cg09736922 | − 0.029; − 0.006 | − 0.245 | 1.99E−06 | 0.960 | 3 | THPO | 0.753 | 0.757 | 1.000 |
cg22539434 | − 0.015; − 0.006 | − 0.246 | 2.03E−06 | 1.000 | 7 | GLI3 | 0.963 | 0.962 | 0.937 |
cg15680660 | − 0.012; − 0.012 | − 0.246 | 2.05E−06 | 1.000 | 3 | XYLB | 0.949 | 0.947 | 1.000 |
cg04547799 | − 0.003; − 0.007 | − 0.234 | 5.80E−06 | 0.860 | 6 | HMGN3 | 0.029 | 0.030 | 0.001 |
cg05797363 | 0.008; − 0.002 | 0.232 | 6.16E−06 | 0.700 | 1 | DEPDC1 | 0.016 | 0.016 | 1.000 |
cg04052235 | 0.03; 0.062 | 0.231 | 7.46E−06 | 0.722 | 11 |  | 0.422 | 0.433 | 1.49E−05 |
cg06002616 | 0.021; 0.105 | 0.225 | 8.37E−06 | 0.039 | 8 | SPAG1 | 0.074 | 0.071 | 1.000 |
cg04769618 | 0.011; 0.015 | 0.230 | 8.70E−06 | 0.874 | 10 | LOC387647 | 0.033 | 0.034 | 1.000 |
cg14685946 | − 0.005; − 0.034 | − 0.222 | 8.73E−06 | 0.002 | 2 | ACSL3 | 0.924 | 0.925 | 1.000 |
PDS-12 – Females | |||||||||
cg07581365 | − 0.005; 0 | − 0.233 | 1.54E−07 | 1.000 | 17 | CBX8 | 0.031 | 0.031 | 1.000 |
cg06988547 | − 0.036; 0.003 | − 0.231 | 1.87E−07 | 1.000 | 1 |  | 0.909 | 0.910 | 1.000 |
cg18397726 | − 0.04; − 0.024 | − 0.217 | 1.38E−06 | 1.000 | 14 | CHGA | 0.949 | 0.949 | 0.016 |
cg07844563 | − 0.002; − 0.014 | − 0.206 | 2.25E−06 | 0.001 | 1 | LOC653566 | 0.959 | 0.956 | 0.038 |
cg08883485 | − 0.033; − 0.085 | − 0.209 | 2.80E−06 | 0.660 | 1 | NAV1 | 0.452 | 0.473 | 4.36E−05 |
cg23204278 | 0.001; 0.001 | 0.211 | 2.87E−06 | 1.000 | 18 |  | 0.012 | 0.012 | 1.000 |
cg10669219 | − 0.02; − 0.008 | − 0.207 | 4.34E−06 | 1.000 | 5 |  | 0.822 | 0.827 | 0.863 |
cg19237923 | − 0.015; − 0.035 | − 0.204 | 5.39E−06 | 0.710 | 1 | NTRK1 | 0.671 | 0.699 | 7.53E−39 |
cg09550127 | − 0.008; − 0.01 | − 0.203 | 6.90E−06 | 1.000 | 6 |  | 0.929 | 0.936 | 1.24E−04 |
cg17052466 | − 0.006; 0.001 | − 0.201 | 8.25E−06 | 1.000 | 11 | TSSC4 | 0.952 | 0.956 | 1.41E−06 |
PDS-14—Males | |||||||||
cg04239863 | 0; − 0.056 | − 0.273 | 8.15E−09 | 9.38E−09 | 16 |  | 0.831 | 0.841 | 0.004 |
cg03115019 | − 0.028; − 0.148 | − 0.256 | 5.28E−07 | 0.040 | 17 | FN3K | 0.837 | 0.848 | 0.012 |
cg22325292 | − 0.044; − 0.291 | − 0.252 | 7.82E−07 | 0.038 | 17 | FN3K | 0.719 | 0.729 | 1.000 |
cg15142913 | − 0.016; − 0.001 | − 0.259 | 7.88E−07 | 0.952 | 8 | PTP4A3 | 0.929 | 0.931 | 1.000 |
cg00008671 | − 0.01; − 0.038 | − 0.247 | 2.06E−06 | 0.350 | 10 | FAM190B | 0.238 | 0.228 | 2.57E−04 |
cg14466923 | 0.002; 0.011 | 0.232 | 3.40E−06 | 1.73E−04 | 6 | COL11A2 | 0.943 | 0.943 | 1.000 |
cg21759953 | 0.006; 0.006 | 0.242 | 5.09E−06 | 1.000 | 2 | GLI2 | 0.917 | 0.918 | 1.000 |
cg18223453 | 0.005; 0.054 | 0.227 | 6.73E−06 | 0.001 | 17 | TBX4 | 0.682 | 0.735 | 3.59E−82 |
cg02763540 | − 0.016; 0.002 | − 0.235 | 8.71E−06 | 0.922 | 19 | UHRF1 | 0.804 | 0.812 | 0.049 |
cg19238380 | − 0.018; − 0.031 | − 0.235 | 9.49E−06 | 0.969 | 1 | LMNA | 0.473 | 0.487 | 1.63E−09 |
cg24786174 | − 0.067; − 0.074 | − 0.236 | 9.83E−06 | 1.000 | 18 | ZNF516 | 0.542 | 0.528 | 1.000 |
cg04230403 | − 0.001; − 0.017 | − 0.224 | 9.98E−06 | 0.001 | 10 | FAS | 0.026 | 0.026 | 1.000 |
PDS-14—Females | |||||||||
cg20599748 | − 0.005; − 0.012 | − 0.238 | 7.39E−08 | 0.390 | 14 | SERPINA10 | 0.953 | 0.955 | 1.000 |
cg13634653 | − 0.002; − 0.006 | − 0.212 | 1.70E−06 | 0.047 | 15 |  | 0.969 | 0.970 | 0.002 |
cg17965926 | 0.001; 0.009 | 0.203 | 2.38E−06 | 5.18E−06 | 8 |  | 0.031 | 0.031 | 1.000 |
cg23130651 | − 0.003; − 0.019 | − 0.203 | 2.40E−06 | 3.14E−06 | 10 | COMMD3 | 0.883 | 0.871 | 9.54E−11 |
cg03551401 | − 0.019; − 0.055 | − 0.208 | 3.46E−06 | 0.286 | 8 | ADCY8 | 0.457 | 0.512 | 8.35E−53 |
cg00083685 | 0.007; 0.033 | 0.206 | 3.62E−06 | 0.114 | 21 | TFF2 | 0.924 | 0.927 | 0.497 |
cg16198723 | − 0.009; − 0.043 | − 0.202 | 3.96E−06 | 0.001 | 3 | CCDC80 | 0.600 | 0.598 | 1.000 |
cg02614024 | − 0.026; 0.014 | − 0.207 | 4.18E−06 | 0.733 | 15 |  | 0.194 | 0.200 | 1.000 |
cg23972915 | − 0.007; − 0.047 | − 0.201 | 4.27E−06 | 4.14E−04 | 14 |  | 0.643 | 0.648 | 0.509 |
cg03351418 | 0.012; 0.008 | 0.202 | 8.55E−06 | 1.000 | 6 | SHPRH | 0.841 | 0.842 | 1.000 |
PA—Males | |||||||||
cg06096446 | 0.014; 0.012 | 0.204 | 1.22E−07 | 1.000 | 6 | TULP4 | 0.719 | 0.697 | 4.02E−07 |
cg09303847 | 0.003; 0.003 | 0.173 | 9.85E−06 | 1.000 | 6 |  | 0.042 | 0.033 | 1.92E−20 |
PA—Females | |||||||||
cg17382841 | − 0.009; − 0.01 | − 0.166 | 2.74E−06 | 1.000 | 5 | EGFLAM | 0.807 | 0.792 | 0.001 |
cg09179916 | − 0.01; − 0.003 | − 0.163 | 3.96E−06 | 1.000 | 5 | EGFLAM | 0.919 | 0.911 | 0.004 |