Fig. 3

Circos plot showing the chromosomal locations of the 58 CpGs associated with PDS or PA. The inner circle shows the standardised effect sizes of the association (scale ranging from − 0.3 to 0.3) with the dashed line representing 0. The shape of the points plotted on the effect size scale determines the variable analysed (PDS or PA) in the model in which the CpG was found, while the colour of the CpG site identifier shows whether the model was performed on males, females or both sexes. The 8 trans-meQTLs of CpG cg08883485 are depicted with the black line inside the circos plot (pink arrowhead pointing to the CpG site and purple arrowhead pointing to the genomic region of the 8 trans-meQTLs). The CpGs with common cis-meQTLs are shown with black square brackets