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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Fig. 1

Workflow diagram of the study. Through a meta-analysis of 450 K and EPIC platforms on 347,521 CpGs, we identified CpG sites associated with PA or PDS at age 12 or 14 (p < 0.00001). We performed univariate twin modelling to assess heritability and to define the proportion of variance attributed to unique and shared environments and investigated potential sex differences in the significant CpG sites. We identified enriched pathways and linked diseases among CpG sites with an absolute effect size > 0.13 by IPA

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Clinical Epigenetics

ISSN: 1868-7083

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