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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma

Fig. 1

RSPO3 promoter DNA methylation and expression status in CCA. A The expression level of RSPO3 in CCA (represented by T in the figure) and adjacent tissue (including normal bile duct or non-tumor tissue, represented by N in the figure) was analyzed using datasets GSE26566, GSE76297, GSE132305, GSE107943, GSE32879, and GSE119337. B The DNA methylation difference of RSPO3 in CCA and adjacent tissues (including normal bile duct or non-tumor tissue) was analyzed in multiple datasets GSE201241, GSE89803, GSE156299, GSE38860, and GSE49656. In the figure, CCA is represented by T and adjacent tissues are represented by N. Methylation levels in the range of 0–1, with larger values representing higher methylation rates. C DNA methylation of the RSPO3 promoter in 6 pairs of in CCA and adjacent tissues. D RT-qPCR analysis of RSPO3 expression in 62 patients with CCA and adjacent tissues. E Kaplan–Meier curves showing overall survival of CCA patients stratified by median RSPO3 expression (high and low expressing tumors; n = 62)

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Clinical Epigenetics

ISSN: 1868-7083

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