Table 5 Insulin and obesity-related associations reported at the 10 IR-associated blood DNA methylation markers identified in the Framingham Heart Study
CpG marker | Closest gene (bp distance) | CpG–trait association previously reported | Reference (PMIDs) |
|---|---|---|---|
cg17901584 | DHCR24 (785) | Fasting insulin (FI), metabolic syndrome, waist circumference (WC), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), body mass index (BMI), hepatic fat | 31197173 (negative association), 33239708, 29,762,635, 25935004, 28194238, 28095459, 29278407, 28002404, 28213390, 27350042, 34183656, 30936141 |
cg15150970 | DNMT3A (0) | FI | 31197173 (positive association) |
cg22948094 | CTNNB1 (64,025) | Not previously reported | |
cg12729894 | MOB2/CTSD (0) | FI | Negative association (identified in a large meta-analysis from CHARGE cohorts – personal communication; not published) |
cg27640302 | TIMM10 (0) | Not previously reported | |
cg00574958 | CPT1A (0) | FI, fasting glucose, BMI, TG, VLDL-C WC, T2D, plasma adiponectin, carbohydrate and fat intake, blood pressure, hepatic fat, metabolic syndrome | 31197173 (negative association), 29278407, 28,213,390, 26110892, 32901515, 29099282, 29762635, 25935004, 28173150, 28002404, 24920721, 28194238, 25583993, 33622391, 28139377, 32930325, 29198723, 36345830, 27350042, 34183656, 31506343, 30936141, 26808626 |
cg17058475 | CPT1A (0) | FI, BMI, TG, VLDL-C, blood pressure, metabolic syndrome | 31197173 (negative association), 29,278,407, 28213390, 24920721, 28194238, 36345830, 27350042, 28095459, 34183656, 26808626 |
cg24590708 | MYO5C (0) | FI, BMI driving changes in DNA methylation | 31,510,868, 31,197,173 (positive association) |
cg11024682 | SREBF1 (0) | FI, BMI, fasting glucose, WC, T2D, TG, LDL-C, HDL-C, hepatic fat | 31197173 (positive association), 29,278,407, 27019061, 28173150, 28213390, 28194238, 25583993, 25935004, 34670603, 29762635, 29099282, 27350042, 34183656, 31506343, 30936141 |
cg06500161 | ABCG1 (0) | FI, HOMA-IR, TG, BMI, HDL-C, T2D, hepatic fat | 31197173 (positive association), 27019061, 24170695 (positive association), 28213390, 29278407, 28213390, 33239103, 33622391, 28194238, 27350042, 34183656, 31506343, 30936141 |