Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Table 2 Main peripheral blood DNA methylation markers associated (P < 10⁻⁵) with HOMA-IR in the Framingham Heart Study

Locus	CpG marker	Chr	b37 Position	Closest Gene (bp distance)	B	SE	P
1p32	cg17901584	1	55,353,706	DHCR24 (785)	− 0.0047	0.0007	*3.0* × 10^–10
2p23	cg15150970	2	25,473,529	DNMT3A (0)	0.0023	0.0005	7.8 × 10^–6
3p22	cg22948094	3	41,172,376	CTNNB1 (64,025)	− 0.0038	0.0009	7.5 × 10^–6
11p15	cg12729894	11	1,774,378	MOB2/CTSD (0)	− 0.0028	0.0006	3.6 × 10^–6
11q12	cg27640302	11	57,296,133	TIMM10 (0)	0.0018	0.0004	4.0 × 10^–6
11q13	cg00574958	11	68,607,622	CPT1A (0)	− 0.0024	0.0003	*1.2* × 10^–12
11q13	cg17058475	11	68,607,737	CPT1A (0)	− 0.0025	0.0005	*3.7* × 10^–8
15q21	cg24590708	15	52,554,357	MYO5C (0)	0.0048	0.0011	9.1 × 10^–6
17p11	cg11024682	17	17,730,094	SREBF1 (0)	0.0016	0.0003	4.7 × 10^–6
21q22	cg06500161	21	43,656,587	ABCG1 (0)	0.0035	0.0004	*3.4* × 10^–16

IR Insulin Resistance, HOMA-IR Homeostatic Model Assessment of IR. Analyses were conducted in the three batches separately and results were combined using a meta-analysis approach; total N = 3167
P values in bold and italic passed the multiple-testing significance threshold (P < 1.1 × 10^-7)
Linear mixed-effects models, adjusted for age, sex, and body mass index, were used to evaluate association of blood DNA methylation (outcome) with HOMA-IR

ISSN: 1868-7083