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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Fig. 6

TGF-β1/SMAD3/HDAC3 mediated EMT is partially dependent on GATA3. A GATA3 protein quantification following knockdown by si-GATA3. (n = 5). B Representative Western blot images and the corresponding quantitative results of E-cadherin, N-cadherin, vimentin, HDAC3, p-SMAD3 and SMAD3 in PBS-treated or TGF-β1 treated primary AT2 cells for 72 h after GATA3 was knocked down or not. (n = 5). C Relative mRNA expression of HDAC3, E-cadherin, N-cadherin and vimentin. (n = 5). (*P < 0.05, **P < 0.01, ***P < 0.001, nsP > 0.05)

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Clinical Epigenetics

ISSN: 1868-7083

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