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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Fig. 1

IPF is characterized by increased HDAC3 expression in human lung tissues and AT2. A Histological analyses showing masson staining and representative images showing immunohistochemical staining of HDAC3 in healthy controls and patients with IPF (× 200, n = 6). B HDAC3 mRNA quantification in patients with IPF vs healthy controls (n = 6). C Representative Western blot images and the corresponding quantitative results for HDAC3 in patients with IPF vs healthy controls (n = 6). D HDAC3 activity in lung tissues from patients with IPF vs healthy controls (n = 6). E Bioinformatics analysis of HDAC3 expression in AT2 cells from patients with IPF vs healthy controls (F). Representative images of HDAC3 and ABCA3 immunofluorescence colocalization staining and quantitation in lung tissues from patients with IPF and healthy controls (× 400, n = 6). (*P < 0.05, **P < 0.01, ***P < 0.001, nsP > 0.05)

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Clinical Epigenetics

ISSN: 1868-7083

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