N6-methyladenosine methylation in kidney injury

Clinical Epigenetics

Table 1 The mechanism of M6A in CKD and AKI

Kidney disease	Cell	Mechanism of injury	M6A regulators	Target	References
CKD	Podocyte	Inflammation	IGF2BP2, METTL3, METTL14	TIMP2, PI3K, Sirt1	[36,37,38]
		Apoptosis	METTL3, METTL14	TIMP2, Sirt1	[36, 38]
		Autophagy	METTL14	Sirt1	[38]
		Pyroptosis	YTHDF2, METT14, METTL3	lncRNA TINCR, PTEN	[39,40,41]
	MCs	Fibrosis	YTHDF1, METTL3	YAP, NSD2	[42, 43]
	MCs	Inflammation	METTL3	lincRNA-Gm4419	[44]
	GECs	Inflammation	METTL14	α-Klotho	[45]
AKI	TECs	Inflammation	IGF2BP1, WTAP, FTO METTL3, ALKBH5	NLRP3, PPAR-α, E2F1 TAB3, MALAT1, miR-21-5p,	[46,47,48,49,50,51,52]
		EMT	METTL14, FTO, METTL3 ALKBH5	PTEN, MALAT1 LncRNA Gas5	[53,54,55]
		Apoptosis	METTL3, METTl14, WTAP FTO, AlKBH5	miR-873-5p, Nrf2 Foxd1, lncRNA121686	[56,57,58,59]
		Ferroptosis	Unknown	mmu-miR-7212-5p, SAT1, ACSL4, NFE2L2	[60, 61]

ISSN: 1868-7083