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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

Fig. 3

EZH2 inhibition potentiates the effect of ATRA in 3D RMS spheroids. 3D cell viability assay of A RD and B RH30 after treatment with ATRA, GSK343 or in combination at 6 and 14 days relative to DMSO control. C RD and D RH30 spheroid diameter relative to DMSO control after 6- and 14-days treatment Data shown are mean values from 3 independent experiments; bars, SD. One Way ANOVA was used to analyse statistical significance compared to the DMSO control (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001). E Microscope images of RD and RH30 spheroids treated with ATRA, GSK343, or combination for 14 days

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Clinical Epigenetics

ISSN: 1868-7083

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